Loss of Bone Morphogenetic Protein-9 Reduces Survival and Increases MMP Activity After Myocardial Infarction

Shreyas Bhave; Michele Esposito; Lija Swain; Xiaoying Qiao; Gregory Martin; Sakshi Wadhwa; Kay Everett; Navin K Kapur

doi:10.1016/j.jacbts.2023.05.017

Loss of Bone Morphogenetic Protein-9 Reduces Survival and Increases MMP Activity After Myocardial Infarction

JACC Basic Transl Sci. 2023 Aug 16;8(10):1318-1330. doi: 10.1016/j.jacbts.2023.05.017. eCollection 2023 Oct.

Authors

Shreyas Bhave¹, Michele Esposito¹, Lija Swain¹, Xiaoying Qiao¹, Gregory Martin¹, Sakshi Wadhwa¹, Kay Everett¹, Navin K Kapur¹

Affiliation

¹ Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA.

Abstract

No studies have explored a functional role for bone morphogenetic protein (BMP)-9, a transforming growth factor-β superfamily ligand, in cardiac remodeling after myocardial infarction (MI). Using BMP-9 null mice, we observed that loss of BMP-9 decreases survival and increases cardiac rupture after MI. We further observed that loss of BMP-9 not only increases collagen abundance, but also promotes matrix metalloproteinase-9 activity and collagen degradation after MI. These findings identify BMP-9 as a necessary component of cardiac remodeling after MI and a potentially important target of therapy to improve outcomes after MI.

Keywords: bone morphogenetic protein-9; fibrosis; matrix metalloproteinase; myocardial infarction.