Does base excess predict kidney injury in neonates with hypoxic-ischemic encephalopathy?

H Gözde Kanmaz Kutman; Gülsüm Kadıoğlu Şimşek; Betül Siyah Bilgin; M Şenol Akin; Fuat Emre Canpolat

doi:10.1016/j.earlhumdev.2023.105911

Does base excess predict kidney injury in neonates with hypoxic-ischemic encephalopathy?

Early Hum Dev. 2024 Jan:188:105911. doi: 10.1016/j.earlhumdev.2023.105911. Epub 2023 Dec 6.

Authors

H Gözde Kanmaz Kutman¹, Gülsüm Kadıoğlu Şimşek², Betül Siyah Bilgin², M Şenol Akin², Fuat Emre Canpolat²

Affiliations

¹ Department of Neonatology, University of Health Sciences, Ankara Bilkent City Hospital, Turkey. Electronic address: gzdekanmaz@gmail.com.
² Department of Neonatology, University of Health Sciences, Ankara Bilkent City Hospital, Turkey.

PMID: 38064918
DOI: 10.1016/j.earlhumdev.2023.105911

Abstract

In neonates with hypoxic-ischemic encephalopathy (HIE), we studied the correlation between cord blood base excess (BE) and kidney function. Among 225 infants, 29 % had oliguria. BE levels differed significantly between oliguric and non-oliguric infants (p < 0.01), with a negative correlation to kidney injury (r = -0.544, p < 0.01). BE < -18 had 85 % specificity and 76 % sensitivity in predicting kidney injury (AUC = 0.88). These findings suggest BE as a valuable indicator of impending kidney injury in HIE infants, though underlying mechanisms may vary.

Keywords: Acute kidney injury; Base excess; Hypoxic-ischemic encephalopathy; Kidney failure; Olyguria.

MeSH terms

Fetal Blood
Humans
Hypoxia-Ischemia, Brain* / complications
Hypoxia-Ischemia, Brain* / epidemiology
Infant
Infant, Newborn
Kidney