Production of pharmaceutical grade [201Tl]Thallous chloride using 30 MeV cyclotron

Sankha Chattopadhyay; Luna Barua; D G Mahesh; Shayantani Ash; Arpit Mitra; Sujata Saha Das; Samarjit Singha; Md Neyar Alam; Madhusmita; Suprakash Roy; Prosenjit Dhang; Mukesh Jain

doi:10.1016/j.apradiso.2023.111128

Production of pharmaceutical grade [²⁰¹Tl]Thallous chloride using 30 MeV cyclotron

Appl Radiat Isot. 2024 Feb:204:111128. doi: 10.1016/j.apradiso.2023.111128. Epub 2023 Nov 30.

Authors

Affiliations

¹ Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India. Electronic address: sankha@vecc.gov.in.
² Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, Kolkata, India.
³ Radiopharmaceutical Laboratory, Board of Radiation and Isotope Technology, Navi Mumbai, India.
⁴ Medical Cyclotron Facility, Variable Energy Cyclotron Centre, Kolkata, India.
⁵ Department of Nuclear Medicine, Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, India.

PMID: 38056282
DOI: 10.1016/j.apradiso.2023.111128

Abstract

Multiple patient doses of [²⁰¹Tl]TlCl has been produced using electrodeposited enriched ²⁰³Tl in 30 MeV cyclotron (Cyclone-30) with 28 MeV proton energy at 50 μA beam current for 8 h. Ion Exchange Column Chromatography (IECC) and liquid-liquid extraction has been employed for semi-automated radiochemical separation and purification of produced [²⁰¹Tl]TlCl. The produced [²⁰¹Tl]TlCl was used in coronary artery disease (CAD) patients.

Keywords: (201)Tl]TlCl; 30 MeV cyclotron; Ischemia; Pharmacopeia; SPECT/CT.

MeSH terms

Cyclotrons*
Pharmaceutical Preparations
Thallium* / analysis

Substances

Pharmaceutical Preparations
Thallium
thallium chloride
Thallium-201