The ups and downs of bone-marrow adipose tissue in space

Guy Trudel; Gerd Melkus; Tammy Liu

doi:10.1016/j.tem.2023.11.003

The ups and downs of bone-marrow adipose tissue in space

Trends Endocrinol Metab. 2024 Feb;35(2):85-87. doi: 10.1016/j.tem.2023.11.003. Epub 2023 Nov 30.

Authors

Guy Trudel¹, Gerd Melkus², Tammy Liu³

Affiliations

¹ Bone and Joint Research Laboratory, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada; Department of Medicine, Division of Physiatry, The Ottawa Hospital, Room 2505G, 505 Smyth Road, Ottawa, Ontario K1H 8M2, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Room 1321, Ottawa, Ontario K1H 8M5, Canada. Electronic address: gtrudel@toh.ca.
² Department of Radiology, Radiation Oncology and Medical Physics, University of Ottawa, Ottawa, Ontario K1H 8M2, Canada.
³ Bone and Joint Research Laboratory, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.

PMID: 38040579
DOI: 10.1016/j.tem.2023.11.003

Abstract

Knowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.

Keywords: bone anabolism; bone marrow adipose tissue; erythropoiesis; space; vertebra.

MeSH terms

Adipose Tissue*
Bone Marrow*
Bone and Bones
Exercise
Humans