New discoveries on how DICER efficiently processes pre-miRNA

Qi Weng; Qi Wu; Quan Zheng

doi:10.1002/mco2.430

New discoveries on how DICER efficiently processes pre-miRNA

MedComm (2020). 2023 Nov 29;4(6):e430. doi: 10.1002/mco2.430. eCollection 2023 Dec.

Authors

Qi Weng¹, Qi Wu², Quan Zheng²

Affiliations

¹ Department of Pharmacy Quzhou People's Hospital The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou China.
² Core Facility Quzhou People's Hospital The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou China.

Abstract

The latest study identified the "GYM motif" on precursor microRNA (pre-miRNA) for the first time and highlighted its key role in DICER specifically recognizing and efficiently cleaving pre-miRNA to produce miRNA. In addition, the dicing state of DICER efficiently processing pre-miRNA was revealed, which was previously difficult to capture.