Laparoscopic Colorectal Cancer Surgery for Patients With Severe Chronic Heart Failure

Anticancer Res. 2023 Dec;43(12):5645-5648. doi: 10.21873/anticanres.16768.

Abstract

Background/aim: Laparoscopic surgery with pneumoperitoneum is not usually recommended for patients with heart failure due to the potential risks associated with cardiopulmonary stress. Few studies, however, have directly examined whether a laparoscopic approach can be used safely in patients with severe chronic heart failure.

Patients and methods: We retrospectively evaluated the safety and feasibility of laparoscopic colorectal cancer surgery in 13 patients with severe chronic heart failure, defined as left ventricular ejection fraction <40% and/or brain natriuretic peptide >100 pg/ml (NT-proBNP >400 pg/ml). Intraoperative hemodynamics, including systolic blood pressure, diastolic blood pressure, mean blood pressure, and heart rate, were carefully monitored.

Results: The median left ventricular ejection fraction value was 35% (18-62%), and the median brain natriuretic peptide value was 171.7 pg/ml (109.5-961.4 pg/ml). The time-series mean ratio of the patients' blood pressure and heart rate during surgery indicated that soon after the induction of general anesthesia, mean blood pressure was significantly decreased (p<0.05) from baseline. In all 13 cases, laparoscopic surgery was performed successfully, with no significant complications.

Conclusion: The present study showed that laparoscopic surgery for colorectal cancer can be performed safely in patients with severe chronic heart failure.

Keywords: Laparoscopic; chronic heart failure; colorectal cancer; surgery.

MeSH terms

  • Biomarkers
  • Colorectal Neoplasms* / complications
  • Colorectal Neoplasms* / surgery
  • Heart Failure* / complications
  • Heart Failure* / surgery
  • Humans
  • Laparoscopy* / adverse effects
  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Retrospective Studies
  • Stroke Volume
  • Ventricular Function, Left

Substances

  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Biomarkers