Assessment of Keratoconus Risk in Very Asymmetric Ectasia Using Corneal Tomographic and Biomechanical Parameters

Xiaoyu Zhang; Lan Ding; Ling Sun; Bingqing Sun; Yangyi Huang; Yishan Qian; Xingtao Zhou

doi:10.2147/OPTH.S439739

Assessment of Keratoconus Risk in Very Asymmetric Ectasia Using Corneal Tomographic and Biomechanical Parameters

Clin Ophthalmol. 2023 Nov 22:17:3569-3577. doi: 10.2147/OPTH.S439739. eCollection 2023.

Authors

Xiaoyu Zhang^#^{1

2

3}, Lan Ding^#^{1

2

3}, Ling Sun^{1

2

3}, Bingqing Sun^{1

2

3}, Yangyi Huang^{1

2

3}, Yishan Qian^#^{1

2

3}, Xingtao Zhou^#^{1

2

3}

Affiliations

¹ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, People's Republic of China.
² Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, People's Republic of China.
³ Shanghai Research Center of Ophthalmology and Optometry, Eye & ENT Hospital, Fudan University, Shanghai, 200031, People's Republic of China.

^# Contributed equally.

Abstract

Purpose: To investigate the relationship between corneal tomographic or biomechanical parameters and risk of keratoconus in very asymmetric ectasia (VAE).

Methods: This retrospective case-control single-centre study included patients with VAE and normal controls. The VAE group had clinical ectasia in one eye and normal topography (VAE-NT) in the fellow eye; VAE-NT eyes were selected for analysis. The control group was selected from corneal refractive surgery candidates; the right eye was enrolled. Scheimpflug-based corneal tomography (Pentacam) and corneal biomechanical assessment (Corvis ST) were performed. Univariate and multivariable logistic regression were performed using Cox proportional hazards models to evaluate keratoconus-associated risk factors. A two-piecewise linear regression model was applied to examine the threshold effect of selected vital paragmeters on the risk of keratoconus according to a smoothing plot.

Results: Threshold effect between tomographic integration and risk of keratoconus was observed. Discrepancy between the central corneal thickness and thinnest corneal thickness (discrepancy CCT vs TCT) greater than 5 μm, discrepancy between the apex corneal thickness and thinnest corneal thickness (discrepancy ACT vs TCT) greater than 3 μm, vector distance between CCT and TCT (distance CCT vs TCT) greater than 0.65 mm indicated a significant increased risk of keratoconus. Risk of keratoconus decreased when distance CCT vs TCT was less than 0.65 mm.

Conclusion: Discrepancy CCT vs TCT, discrepancy ACT vs TCT, and distance CCT vs TCT can be used as indicators for risk assessment of early keratoconus.

Keywords: corneal biomechanical; corneal tomographic; keratoconus; very asymmetric ectasia.

Grants and funding

This study was supported by the National Natural Science Foundation of China (Grant No. 82371096), Joint Research Project of New Frontier Technology in Municipal Hospitals (SHDC12018103), Project of Shanghai Science and Technology (Grant No.20410710100), Clinical Research Plan of SHDC (SHDC2020CR1043B), and Project of Shanghai Xuhui District Science and Technology (XHLHGG202104).