[A pharmacologic approach to treatment of Mycobacterium abscessus pulmonary disease]

Abstract

Mycobacterium abscessus is a fast-growing non-tuberculous mycobacteria complex causing pulmonary infections, comprising the subspecies abscessus, massiliense and bolletii. Differences are based predominantly on natural inducible macrolide resistance, active in most Mycobacterium abscessus spp abscessus species and in Mycobacterium abscessus spp bolletii but inactive in Mycobacterium abscessus spp massiliense. Therapy consists in long-term treatment, combining multiple antibiotics. Prognosis is poor, as only 40% of patients experience cure. Pharmacodynamic and pharmacokinetic data on M. abscessus have recently been published, showing that therapy ineffectiveness might be explained by intrinsic bacterial resistance (macrolides…) and by the unfavorable pharmacokinetics of the recommended antibiotics. Other molecules and inhaled antibiotics are promising.

Keywords: Antibiotiques inhalés; Inhaled antibiotics; Mycobacterium abscessus; Mycobactérie non tuberculeuse; Non tuberculous mycobacteria; Pharmacologie; Pharmacology; Pneumonia; Pneumonie.