Deep Brain Stimulation for Children with Generalized Epilepsy

Rory J Piper; George M Ibrahim; Martin M Tisdall

doi:10.1016/j.nec.2023.09.002

Deep Brain Stimulation for Children with Generalized Epilepsy

Neurosurg Clin N Am. 2024 Jan;35(1):17-25. doi: 10.1016/j.nec.2023.09.002. Epub 2023 Sep 27.

Authors

Rory J Piper¹, George M Ibrahim², Martin M Tisdall³

Affiliations

¹ Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Neurosurgery, Great Ormond Street Hospital, London, UK. Electronic address: Rory.Piper.20@ucl.ac.uk.
² Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Ontario, Canada.
³ Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Neurosurgery, Great Ormond Street Hospital, London, UK.

PMID: 38000839
DOI: 10.1016/j.nec.2023.09.002

Abstract

Intracranial neuromodulation is an evolving therapy for patients with drug-resistant epilepsy (DRE). Deep brain stimulation (DBS) is now available as a therapy for patients with DRE and focal-onset seizures in select health care systems; however, there remains a substantial need of efficacy data before DBS can be more widely adopted into routine clinical practice. This review and commentary focuses on a particular shifting paradigm: DBS as a therapy for children with generalized-onset seizures.

Keywords: Children; Deep brain stimulation; Epilepsy; Generalized epilepsy; Neuromodulation; Pediatrics.

Publication types

Review

MeSH terms

Child
Deep Brain Stimulation*
Drug Resistant Epilepsy* / etiology
Drug Resistant Epilepsy* / therapy
Epilepsy, Generalized* / etiology
Epilepsy, Generalized* / therapy
Humans
Seizures / therapy
Treatment Outcome