Prototype of a new protamine sulphate titration kit for use in cardiopulmonary bypass surgery

S Afr Med J. 1986 Dec 20;70(13):809-11.

Abstract

A new protamine sulphate titration kit has been developed and tested in patients undergoing cardiac bypass surgery. When a prototype of the kit was used, protamine sulphate dosage was significantly reduced (P less than 0.01) without a significant increase in 24-hour postoperative blood loss (P greater than 0.05).

MeSH terms

  • Adult
  • Cardiopulmonary Bypass*
  • Evaluation Studies as Topic
  • Heparin Antagonists / analysis
  • Heparin Antagonists / therapeutic use
  • Humans
  • Protamines / analysis*
  • Protamines / therapeutic use
  • Random Allocation
  • Reagent Kits, Diagnostic / standards*

Substances

  • Heparin Antagonists
  • Protamines
  • Reagent Kits, Diagnostic