Incorporating Exercise Training into Cardio-Oncology Care: Current Evidence and Opportunities: JACC: CardioOncology State-of-the-Art Review

Rebekah L Wilson; Cami N Christopher; Eric H Yang; Ana Barac; Scott C Adams; Jessica M Scott; Christina M Dieli-Conwright

doi:10.1016/j.jaccao.2023.08.008

Incorporating Exercise Training into Cardio-Oncology Care: Current Evidence and Opportunities: JACC: CardioOncology State-of-the-Art Review

JACC CardioOncol. 2023 Oct 17;5(5):553-569. doi: 10.1016/j.jaccao.2023.08.008. eCollection 2023 Oct.

Authors

Rebekah L Wilson^{1

2}, Cami N Christopher^{1

3}, Eric H Yang⁴, Ana Barac⁵, Scott C Adams^{6

7}, Jessica M Scott^{8

9}, Christina M Dieli-Conwright^{1

2

3}

Affiliations

¹ Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
² Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
³ Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
⁴ Cardio-Oncology Program, Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁵ Inova Schar Heart and Vascular and Inova Schar Cancer Institute, Falls Church, Virginia, USA.
⁶ Department of Cardiology, Toronto General Hospital Research Institute, Toronto, Ontario, Canada.
⁷ Ted Rogers Cardiotoxicity Prevention Program, Peter Munk Cardiac Centre, Toronto, Ontario, Canada.
⁸ Memorial Sloan Kettering Cancer Center, New York, New York, USA.
⁹ Weill Cornell Medical College, New York, New York, USA.

Abstract

Cancer treatment-induced cardiotoxicities are an ongoing concern throughout the cancer care continuum from treatment initiation to survivorship. Several "standard-of-care" primary, secondary, and tertiary prevention strategies are available to prevent the development or further progression of cancer treatment-induced cardiotoxicities and their risk factors. Despite exercise's established benefits on the cardiovascular system, it has not been widely adopted as a nonpharmacologic cardioprotective strategy within cardio-oncology care. In this state-of-the-art review, the authors discuss cancer treatment-induced cardiotoxicities, review the existing evidence supporting the role of exercise in preventing and managing these sequelae in at-risk and affected individuals living after cancer diagnoses, and propose considerations for implementing exercise-based services in cardio-oncology practice.

Keywords: cancer; cardio-oncology; cardiotoxicities; exercise.

Publication types

Review

Grants and funding

P30 CA008748/CA/NCI NIH HHS/United States