Neutrophils sing "IL[-10] be seeing you" in the lungs during pneumonia

Matthew K McPeek; John C Gomez; Claire M Doerschuk

doi:10.1093/jleuko/qiad134

Neutrophils sing "IL[-10] be seeing you" in the lungs during pneumonia

J Leukoc Biol. 2024 Jan 5;115(1):1-3. doi: 10.1093/jleuko/qiad134.

Authors

Matthew K McPeek¹, John C Gomez¹, Claire M Doerschuk^{1

2}

Affiliations

¹ Marsico Lung Institute, University of North Carolina at Chapel Hill, 125 Mason Farm Rd, Chapel Hill, NC 27599-7248, United States.
² Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, 130 Mason Farm Rd, Chapel Hill, NC 27599, United States.

PMID: 37931143
DOI: 10.1093/jleuko/qiad134

Abstract

Mechanisms of regulating the beneficial and harmful capabilities of neutrophils include IL-10/IL-10RA signaling in neutrophils that limits clearance of Streptococcus pneumoniae and accumulation of neutrophils in pneumonic lung tissue.

Publication types

Editorial
Comment

MeSH terms

Humans
Interleukin-10
Lung
Neutrophils / physiology
Pneumonia*
Streptococcus pneumoniae*

Substances

Interleukin-10