Biomarkers of response to topical crisaborole in patients with mild/moderate pediatric atopic dermatitis from minimally invasive tape strip transcriptome

Anna B Fishbein; Janak Mukherji; Michael Demczuk; Brooke Buranosky; Jack Osborn; Crista Moreno; Dominic LaRoche; Amy S Paller; Kurt Q Lu

doi:10.1016/j.jaad.2023.10.057

Biomarkers of response to topical crisaborole in patients with mild/moderate pediatric atopic dermatitis from minimally invasive tape strip transcriptome

J Am Acad Dermatol. 2024 Mar;90(3):629-632. doi: 10.1016/j.jaad.2023.10.057. Epub 2023 Nov 3.

Authors

Anna B Fishbein¹, Janak Mukherji², Michael Demczuk³, Brooke Buranosky², Jack Osborn², Crista Moreno⁴, Dominic LaRoche⁴, Amy S Paller³, Kurt Q Lu³

Affiliations

¹ Division of Pediatric Allergy & Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois. Electronic address: afishbein@luriechildrens.org.
² Division of Pediatric Allergy & Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois.
³ Division of Dermatology, Department of Dermatology, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois.
⁴ HTG Molecular Diagnostics, Tucson, Arizona.

PMID: 37924950
DOI: 10.1016/j.jaad.2023.10.057

No abstract available

Keywords: RNAseq; atopic dermatitis; biomarkers; crisaborole; minimally invasive tape strip; molecular; pediatric atopic dermatitis; phosphodiesterase-4 inhibitor; tape strips; transcriptome.

MeSH terms

Biomarkers
Boron Compounds / therapeutic use
Bridged Bicyclo Compounds, Heterocyclic / therapeutic use
Child
Dermatitis, Atopic* / drug therapy
Humans
Ointments
Transcriptome

Substances

crisaborole
Boron Compounds
Bridged Bicyclo Compounds, Heterocyclic
Biomarkers
Ointments

Grants and funding

P30 AR075049/AR/NIAMS NIH HHS/United States