Abstract
Iproplatin was evaluated in a phase I study in children to determine the maximum tolerated dosage. The dose-limiting toxic effect was found to be myelosuppression, which in part was related to the amount of prior therapy with irradiation and other anticancer agents. The dosage recommended for phase II trials in children is 324 mg/m2 iv over 2 hours every 3-4 weeks.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Child
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Child, Preschool
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Drug Administration Schedule
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Drug Evaluation
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Female
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Hematologic Diseases / chemically induced
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Humans
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Infant
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Male
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / adverse effects
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Organoplatinum Compounds / therapeutic use*
Substances
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Organoplatinum Compounds
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iproplatin