Innate lymphoid cells: a new key player in atopic dermatitis

Front Immunol. 2023 Oct 16:14:1277120. doi: 10.3389/fimmu.2023.1277120. eCollection 2023.

Abstract

Atopic dermatitis (AD) is a common allergic inflammatory skin condition mainly caused by gene variants, immune disorders, and environmental risk factors. The T helper (Th) 2 immune response mediated by interleukin (IL)-4/13 is generally believed to be central in the pathogenesis of AD. It has been shown that innate lymphoid cells (ILCs) play a major effector cell role in the immune response in tissue homeostasis and inflammation and fascinating details about the interaction between innate and adaptive immunity. Changes in ILCs may contribute to the onset and progression of AD, and ILC2s especially have gained much attention. However, the role of ILCs in AD still needs to be further elucidated. This review summarizes the role of ILCs in skin homeostasis and highlights the signaling pathways in which ILCs may be involved in AD, thus providing valuable insights into the behavior of ILCs in skin homeostasis and inflammation, as well as new approaches to treating AD.

Keywords: atopic dermatitis; cytokines; inflammatory response; innate lymphoid cells; pathophysiology.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytokines / metabolism
  • Dermatitis, Atopic*
  • Humans
  • Immunity, Innate
  • Inflammation
  • Interleukin-13 / metabolism
  • Lymphocytes

Substances

  • Cytokines
  • Interleukin-13

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Key Research and Development Project of the Sichuan Provincial Science and Technology Department (2023YFS0311, 2022YFS0310), the Sichuan Provincial Health Commission Project (21PJ088), and the University of Electronic Science and Technology of China (ZYGX2021YGLH217).