Back To Basics: Theory of Thrombus Formation and Potential Implications for Therapies?

M Silena Mosquera; Jose A Diaz

doi:10.1016/j.tvir.2023.100894

Back To Basics: Theory of Thrombus Formation and Potential Implications for Therapies?

Tech Vasc Interv Radiol. 2023 Jun;26(2):100894. doi: 10.1016/j.tvir.2023.100894. Epub 2023 Aug 6.

Authors

M Silena Mosquera¹, Jose A Diaz²

Affiliations

¹ Department of Surgery, Center for Fetal Research, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA.
² Division of Surgical Research, Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN. Electronic address: jose.a.diaz@vumc.org.

PMID: 37865449
DOI: 10.1016/j.tvir.2023.100894

Abstract

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and potentially fatal condition. Despite existing treatments, recurrence rates and complications remain high. Understanding the pathophysiology of thrombus formation is crucial for developing effective therapies. This narrative review provides an overview of the critical elements of acute and chronic DVT, presents a theoretical framework for understanding thrombus formation, and discusses potential implications for therapeutic interventions. In addition, a hypothesis of thrombus formation is formulated, encompassing all elements described in this work.

Keywords: DVT; VTE; Venous thrombosis; coagulation; endothelium; thrombus initiation.

Publication types

Review

MeSH terms

Anticoagulants / therapeutic use
Humans
Pulmonary Embolism* / diagnostic imaging
Pulmonary Embolism* / therapy
Risk Factors
Thrombosis* / complications
Thrombosis* / drug therapy
Venous Thromboembolism*
Venous Thrombosis* / diagnostic imaging
Venous Thrombosis* / therapy

Substances

Anticoagulants