Rapid spread of a novel NDM-producing clone of Klebsiella pneumoniae CC147, Northern Italy, February to August 2023

Irene Mileto; Greta Petazzoni; Marta Corbella; Stefano Gaiarsa; Cristina Merla; Angela Kuka; Marina Ramus; Cristina Terulla; Micaela Brandolini; Antonio Piralla; Patrizia Cambieri; Fausto Baldanti

doi:10.2807/1560-7917.ES.2023.28.42.2300522

Rapid spread of a novel NDM-producing clone of Klebsiella pneumoniae CC147, Northern Italy, February to August 2023

Euro Surveill. 2023 Oct;28(42):2300522. doi: 10.2807/1560-7917.ES.2023.28.42.2300522.

Authors

Irene Mileto^{1

2

3}, Greta Petazzoni^{1

4

3}, Marta Corbella¹, Stefano Gaiarsa¹, Cristina Merla¹, Angela Kuka¹, Marina Ramus^{1

2}, Cristina Terulla⁵, Micaela Brandolini⁶, Antonio Piralla¹, Patrizia Cambieri^{1

7}, Fausto Baldanti^{1

4

7}

Affiliations

¹ Microbiology and Virology Unit, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
² Specialization School of Microbiology and Virology, University of Pavia, Pavia, Italy.
³ These authors have contributed equally.
⁴ Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy.
⁵ ASST Pavia, Ospedale Civile di Voghera, Voghera, Italy.
⁶ ASST Pavia, Ospedale Unificato Broni-Stradella, Internal Medicine Unit, Stradella, Italy.
⁷ These authors contributed equally to the work and share the last authorship.

PMID: 37855902
PMCID: PMC10588309
DOI: 10.2807/1560-7917.ES.2023.28.42.2300522

Abstract

New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae (Kp) ST147 caused a large multi-hospital outbreak in Italy from 2018 to 2021. We describe a new ST6668 NDM-producing Kp clone, belonging to CC147, which rapidly spread across hospitals in the Pavia province (Northern Italy) from February to August 2023. Genomic analyses revealed that ST6668 is different from ST147 and fast evolving. As shown here, genomic surveillance programmes are useful for tracking the spread of new clones with reduced susceptibility to most antibiotics.

Keywords: Klebsiella pneumoniae; NDM-producing; epidemiology; genomics; public health; surveillance.

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Disease Outbreaks
Humans
Italy / epidemiology
Klebsiella Infections* / drug therapy
Klebsiella Infections* / epidemiology
Klebsiella pneumoniae* / genetics
Microbial Sensitivity Tests
beta-Lactamases / genetics

Substances

beta-Lactamases
Anti-Bacterial Agents