Long-term tonic spinal cord stimulation in advanced Parkinson's disease: No effect from stimulation under placebo-controlled evaluation

Rafael Bernhart Carra; Tamine Teixeira da Costa Capato; Janaina Reis Menezes; Egberto Reis Barbosa; Kleber Paiva Duarte; Manoel Jacobsen Teixeira; Rubens Gisbert Cury

doi:10.1016/j.prdoa.2023.100220

Long-term tonic spinal cord stimulation in advanced Parkinson's disease: No effect from stimulation under placebo-controlled evaluation

Clin Park Relat Disord. 2023 Oct 6:9:100220. doi: 10.1016/j.prdoa.2023.100220. eCollection 2023.

Authors

Rafael Bernhart Carra¹, Tamine Teixeira da Costa Capato¹, Janaina Reis Menezes¹, Egberto Reis Barbosa¹, Kleber Paiva Duarte², Manoel Jacobsen Teixeira², Rubens Gisbert Cury¹

Affiliations

¹ Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.
² Functional Neurosurgery Division, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.

Abstract

•Chronic spinal cord stimulation effectiveness was evaluated in four PD patients.•Double blinded cross over evaluation was performed using subthreshold stimulation.•An open label evaluation with regular suprathreshold stimulation was also performed.•No statistically significant effect was produced with either stimulation.•This study highlights the lack of strong clinical evidence supporting SCS for PD.

Keywords: Freezing of Gait; Parkinson’s Disease; Spinal Cord Stimulation.