Multiple rhabdomyomatous mesenchymal hamartomas in a patient with mosaic Barber-Say syndrome

Pediatr Dermatol. 2024 Mar-Apr;41(2):307-310. doi: 10.1111/pde.15436. Epub 2023 Oct 10.

Abstract

Barber-Say syndrome (BSS) is a rare congenital ectodermal dysplasia with few cases reported in the literature. We describe a 9-year-old boy with congenital generalized hypertrichosis and multiple rhabdomyomatous mesenchymal hamartomas (RMHs) on his nose and periocular region. Next-generation sequencing, performed in DNA from a blood sample, and RMH tissue, revealed a pathogenic variant in the TWIST2 gene, which was not detected in a salivary sample of the patient, nor in his parents. Therefore, we consider this variant as de novo mosaicism. To our knowledge, this is the first case of multiple RMHs associated with BSS.

Keywords: Barber-Say syndrome; TWIST2; multiple rhabdomyomatous mesenchymal hamartomas.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple* / genetics
  • Child
  • Eyelid Diseases*
  • Hamartoma* / complications
  • Hamartoma* / diagnosis
  • Hamartoma* / genetics
  • Hirsutism / genetics
  • Humans
  • Hypertelorism*
  • Hypertrichosis* / congenital
  • Hypertrichosis* / genetics
  • Macrostomia*
  • Male
  • Skin Abnormalities*

Supplementary concepts

  • Barber Say syndrome