The Inhibitory Effect of Platelet Aggregation Ability Assessed by the Platelet Aggregatory Threshold Index in a Patient with Recurrent Stent Thrombosis

Intern Med. 2024 May 15;63(10):1381-1386. doi: 10.2169/internalmedicine.2545-23. Epub 2023 Oct 6.

Abstract

An 86-year-old man successfully underwent percutaneous coronary intervention (PCI), in which a drug-coated stent (DCS) was placed in the left anterior descending coronary artery. However, stent thrombosis occurred twice after eight and two months. After the second admission, the patient was tested for platelet aggregation activity using the platelet aggregation threshold index (PATI), and insufficient inhibition of platelet aggregation was observed. The patient's PATI improved to a satisfactory level using oral anticoagulants. At the six-month follow-up, clinical events were observed. Measuring the platelet aggregation ability can help clinicians understand the pathology of patients and determine treatment choices.

Keywords: angina pectoris; anti-platelet therapy; cardiovascular disease; platelet aggregation; stent thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Anticoagulants / therapeutic use
  • Coronary Thrombosis / blood
  • Coronary Thrombosis / etiology
  • Drug-Eluting Stents* / adverse effects
  • Humans
  • Male
  • Percutaneous Coronary Intervention*
  • Platelet Aggregation Inhibitors / therapeutic use
  • Platelet Aggregation* / drug effects
  • Platelet Aggregation* / physiology
  • Platelet Function Tests
  • Recurrence*
  • Stents / adverse effects
  • Thrombosis / etiology