Seed Becoming Soil: A New Paradigm of the Ewing Sarcoma Tumor Microenvironment

Christopher Kuo; James F Amatruda

doi:10.1158/1078-0432.CCR-23-2259

Seed Becoming Soil: A New Paradigm of the Ewing Sarcoma Tumor Microenvironment

Clin Cancer Res. 2023 Dec 15;29(24):5002-5004. doi: 10.1158/1078-0432.CCR-23-2259.

Authors

Christopher Kuo^{1

2}, James F Amatruda^{1

2

3}

Affiliations

¹ Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California.
² Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California.
³ Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Abstract

Cells in the tumor microenvironment, including cancer-associated fibroblasts (CAF), contribute to tumor growth and immune evasion. A recent study of Ewing sarcoma identified "CAF-like" tumor cells that mimic the protumorigenic features of CAFs. These findings highlight the role of cell plasticity in tumor growth. See related article by Wrenn et al., p. 5140.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cancer-Associated Fibroblasts* / pathology
Fibroblasts
Humans
Sarcoma, Ewing* / genetics
Sarcoma, Ewing* / pathology
Soil
Tumor Microenvironment

Substances

Soil

Abstract

Publication types

MeSH terms

Substances

Grants and funding