Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis

Virol Sin. 2023 Dec;38(6):971-974. doi: 10.1016/j.virs.2023.09.005. Epub 2023 Sep 30.

Abstract

  1. Establishment of 3D cardiac organoids composed of cardiomyocyte and endothelial layers.

  2. SARS-CoV-2 infection causes multi-lineage cardiac injuries.

  3. Cardiovascular health should be greatly concerned in COVID-19 patients.

Publication types

  • Letter

MeSH terms

  • COVID-19*
  • Humans
  • Induced Pluripotent Stem Cells*
  • Myocarditis*
  • SARS-CoV-2