Lymphadenitis caused by Purpureocillium lilacinum in a patient with CARD9 deficiency

Hidetaka Majima; Yuzaburo Inoue; Yuichiro Otsuka; Takashi Yaguchi; Akira Watanabe; Katsuhiko Kamei

doi:10.1016/j.mmcr.2023.100609

Lymphadenitis caused by Purpureocillium lilacinum in a patient with CARD9 deficiency

Med Mycol Case Rep. 2023 Sep 18:42:100609. doi: 10.1016/j.mmcr.2023.100609. eCollection 2023 Dec.

Authors

Hidetaka Majima¹, Yuzaburo Inoue², Yuichiro Otsuka³, Takashi Yaguchi⁴, Akira Watanabe¹, Katsuhiko Kamei^{5

6}

Affiliations

¹ Division of Clinical Research, Medical Mycology Research Center, Chiba University, Chiba, Japan.
² Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
³ Division of Otolaryngology, Chiba Kaihin Municipal Hospital, Chiba, Japan.
⁴ Management of Unit of Microbiological Resources, Medical Mycology Research Center, Chiba University, Chiba, Japan.
⁵ Department of Infectious Disease, Japanese Red Cross Ishinomaki Hospital, Miyagi, Japan.
⁶ Division of Infection Control and Prevention, Medical Mycology Research Center, Chiba University, Chiba, Japan.

Abstract

We hereby make the first report of a case of mycosis caused by Purpureocillium lilacinum in CARD9 deficiency. A 40-year-old woman complained of lymph node swellings in the left cervical area. She also had chronic mucocutaneous candidiasis (CMC), and was found to have CARD9 deficiency. Lymphadenitis by P. lilacinum was confirmed. The diagnosis was difficult, as culturing the biopsy specimen at a cautiously selected temperature (25 °C) and genetic analysis were both required. Oral administration of voriconazole improved her lymphadenopathy.

Keywords: CARD9 deficiency; Lymphadenitis; Purpureocillium lilacinum.

Publication types

Case Reports