Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation

Abstract

Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.

Keywords: Clinical immunology; Cryopreservation; Thymopoiesis; Thymus transplantation.