Hepatic soluble epoxide hydrolase: A promising target for unveiling the liver-brain axis in Alzheimer's disease

Neuron. 2023 Sep 20;111(18):2775-2777. doi: 10.1016/j.neuron.2023.08.019.

Abstract

Wu and Dong et al.1 report that hepatic soluble epoxide hydrolase (sEH) manipulation impacts amyloid-β (Aβ) deposits and cognitive impairment in mouse models for Alzheimer's disease (AD), suggesting that hepatic sEH activity is a promising therapeutic target to treat AD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Alzheimer Disease*
  • Amyloid beta-Peptides
  • Animals
  • Brain
  • Epoxide Hydrolases*
  • Liver
  • Mice

Substances

  • Epoxide Hydrolases
  • Amyloid beta-Peptides