Nuclear magnetic resonance spectroscopic analysis of myo-inositol phosphates including inositol 1,3,4,5-tetrakisphosphate

J Biol Chem. 1986 Nov 5;261(31):14676-80.

Abstract

1H and 31P NMR spectra of a variety of phosphorylated myo-inositols have been analyzed using a Bruker WH-360 spectrometer. Proton and phosphorus chemical shifts and coupling constants are reported for myo-inositol 1-phosphate, myo-inositol 2-phosphate, myo-inositol 5-phosphate, myo-inositol 1,2-cyclic phosphate, myo-inositol 1,4-bisphosphate, myo-inositol 1,4,5-trisphosphate, and myo-inositol 1,3,4,5-tetrakisphosphate. These data provide the basis for the chemical identification and characterization of biologically relevant inositol phosphates.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Hydrogen
  • Inositol Phosphates*
  • Magnetic Resonance Spectroscopy / methods
  • Molecular Conformation
  • Phosphorus
  • Structure-Activity Relationship
  • Sugar Phosphates*

Substances

  • Inositol Phosphates
  • Sugar Phosphates
  • inositol-1,3,4,5-tetrakisphosphate
  • Phosphorus
  • Hydrogen