Identification of hidden N4-like viruses and their interactions with hosts

Kaiyang Zheng; Yantao Liang; David Paez-Espino; Xiao Zou; Chen Gao; Hongbing Shao; Yeong Yik Sung; Wen Jye Mok; Li Lian Wong; Yu-Zhong Zhang; Jiwei Tian; Feng Chen; Nianzhi Jiao; Curtis A Suttle; Jianfeng He; Andrew McMinn; Min Wang

doi:10.1128/msystems.00197-23

Identification of hidden N4-like viruses and their interactions with hosts

mSystems. 2023 Oct 26;8(5):e0019723. doi: 10.1128/msystems.00197-23. Epub 2023 Sep 13.

Authors

Kaiyang Zheng^#^{1

2}, Yantao Liang^#^{1

2}, David Paez-Espino^#^{3

4}, Xiao Zou⁵, Chen Gao^{1

2}, Hongbing Shao^{1

2}, Yeong Yik Sung^{2

6}, Wen Jye Mok^{2

6}, Li Lian Wong^{2

6}, Yu-Zhong Zhang^{1

7}, Jiwei Tian⁸, Feng Chen⁹, Nianzhi Jiao¹⁰, Curtis A Suttle^{11

12

13}, Jianfeng He¹⁴, Andrew McMinn^{1

15}, Min Wang^{1

2

16}

Affiliations

¹ Key Laboratory of Polar Oceanography and Global Ocean Change, Frontiers Science Center for Deep Ocean Multispheres and Earth System, College of Marine Life Sciences, Institute of Evolution and Marine Biodiversity, Ocean University of China , Qingdao, China.
² UMT-OUC Joint Centre for Marine Studies , Qingdao, China.
³ DOE Joint Genome Institute, Lawrence Berkeley National Laboratory , Berkeley, California, USA.
⁴ Mammoth Biosciences Inc. , South San Francisco, California, USA.
⁵ Qingdao Central Hospital , Qingdao, China.
⁶ Institute of Marine Biotechnology, Universiti Malaysia Terengganu (UMT) , Kuala Terengganu, Malaysia.
⁷ State Key Laboratory of Microbial Technology, Marine Biotechnology Research Center, Shandong University , Qingdao, China.
⁸ Key Laboratory of Physical Oceanography, Ministry of Education, Ocean University of China , Qingdao, China.
⁹ Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Science , Baltimore, Maryland, USA.
¹⁰ State Key Laboratory of Marine Environmental Sciences, Institute of Marine Microbes and Ecospheres, Xiamen University , Xiamen, China.
¹¹ Department of Earth, Ocean and Atmospheric Sciences, Institute for the Oceans and Fisheries, The University of British Columbia , Vancouver, British Columbia, Canada.
¹² Department of Microbiology and Immunology, Institute for the Oceans and Fisheries, The University of British Columbia , Vancouver, British Columbia, Canada.
¹³ Department of Botany, Institute for the Oceans and Fisheries, The University of British Columbia , Vancouver, British Columbia, Canada.
¹⁴ SOA Key Laboratory for Polar Science, Polar Research Institute of China , Shanghai, China.
¹⁵ Institute for Marine and Antarctic Studies, University of Tasmania , Hobart, Tasmania, Australia.
¹⁶ The Affiliated Hospital of Qingdao University , Qingdao, China.

^# Contributed equally.

Abstract

The findings of this study are significant, as N4-like viruses represent a unique viral lineage with a distinct replication mechanism and a conserved core genome. This work has resulted in a comprehensive global map of the entire N4-like viral lineage, including information on their distribution in different biomes, evolutionary divergence, genomic diversity, and the potential for viral-mediated host metabolic reprogramming. As such, this work significantly contributes to our understanding of the ecological function and viral-host interactions of bacteriophages.

Keywords: N4-like viruses; diversity; evolutionary divergence; genome; viral-mediated host metabolic reprogramming.

MeSH terms

Bacteriophages* / genetics
Genome, Viral / genetics
Genomics
Phylogeny
Viruses* / genetics

Abstract

MeSH terms

Grants and funding