A Comparative Study of Dexamethasone Ointment along with Triamcinolone Acetonide in Treatment of Recurrent Aphthous Stomatitis

Rakhee; Vivek Kumar; Chintu Kumar Singh; Ananya Arvind; Aasia Ahsan; Sudhanshu Kumar; Debeswar Das; Subham Kumari

doi:10.4103/jpbs.jpbs_102_23

A Comparative Study of Dexamethasone Ointment along with Triamcinolone Acetonide in Treatment of Recurrent Aphthous Stomatitis

J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1325-S1328. doi: 10.4103/jpbs.jpbs_102_23. Epub 2023 Apr 28.

Authors

Rakhee¹, Vivek Kumar², Chintu Kumar Singh³, Ananya Arvind⁴, Aasia Ahsan⁵, Sudhanshu Kumar⁶, Debeswar Das⁷, Subham Kumari⁸

Affiliations

¹ Department of Oral Medicine and Radiology, Vananchal Dental College and Hospital, Garhwa, Jharkhand, India.
² Department of Oral and Maxillofacial Surgery, B.R. Ambedkar Institute of Dental Science and Hospital, Patna, Bihar, India.
³ Department of Oral and Maxillofacial Pathology and Microbiology, Aditya Dental College and Hospital, Beed, India.
⁴ IGIMS, Patna, Bihar, India.
⁵ Department of Prosthodontics Crown and Bridge, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.
⁶ MDS, Oral Medicine and Radiology, Private Practice, Madhepura, Bihar, India.
⁷ Oral Pathology and Microbiology and Forensic Odontology, Regional Dental College, Gwahati, India.
⁸ BDS, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.

Abstract

Aim: To assess and compare the efficacy of dexamethasone ointment with triamcinolone acetonide, the gel form, in the treatment of minor recurrent aphthous stomatitis (RAS).

Materials and methods: This was a randomized clinical trial of 60 patients of either sex with clinically diagnosed RAS who were randomly divided into two groups-the dexamethasone ointment group (Group I) and the triamcinolone acetonide gel group (Group II). Patients were asked to apply the gel three times a day on each ulcer. Estimation of the efficacy of gel was done based on the time required for regression in pain, size, and number of ulcers.

Results: The results showed there was a significant difference in size, pain, number, and duration of ulcers in Group I and Group II within 7 days. However, in both groups, no significant difference was noted in the treatment of RAS.

Conclusion: Dexamethasone ointment was found to be efficient in this treatment and was safe as evaluated using clinical assessments.

Keywords: Dexamethasone ointment; recurrent aphthous stomatitis; triamcinolone acetonide.