Bilateral adrenal giant medullary lipoma combined with disorders of sex development: a rare case report and literature review

Chenghao Zhanghuang; Na Long; Zhen Yang; Yucheng Xie

doi:10.3389/fonc.2023.1210679

Bilateral adrenal giant medullary lipoma combined with disorders of sex development: a rare case report and literature review

Front Oncol. 2023 Aug 23:13:1210679. doi: 10.3389/fonc.2023.1210679. eCollection 2023.

Authors

Chenghao Zhanghuang^{1

2}, Na Long³, Zhen Yang⁴, Yucheng Xie^{5

6}

Affiliations

¹ Department of Urology, Kunming Children's Hospital, Yunnan Province Clinical Research Center for Children's Health and Disease, Kunming, China.
² Yunnan Key Laboratory of Children's Major Disease Research, Yunnan Clinical Medical Center for Pediatric Diseases, Kunming Children's Hospital, Kunming, China.
³ Special Ward, Kunming Children's Hospital, Yunnan Province Clinical Research Center for Children's Health and Disease, Kunming, China.
⁴ Department of Oncology, Yunnan Children Solid Tumor Treatment Center, Kunming Children's Hospital, Kunming, China.
⁵ Department of Pathology, Kunming Children's Hospital, Kunming, China.
⁶ Department of Pathology, The Second People's Hospital of Yunnan Province, Kunming, China.

Abstract

Bilateral adrenal myelolipoma is rare in clinics and patients with disorders of sex development (DSDs). One case was reported in our center. A 45-year-old patient was admitted to the hospital after discovering a left abdominal mass for more than a year and worsening abdominal pain for 18 days. An imaging examination showed bilateral adrenal masses. Physical examination showed clitoris hypertrophy with patelliform changes, thick and dense pubic hair, normal development of bilateral labia majora without labia minora, and urethral opening. After the relevant preoperative examinations, bilateral adrenal mass resection was performed under general anesthesia. The postoperative pathology confirmed adrenal myelolipoma. The incision healed well without recurrence over 10 years after the operation. Her enlarged clitoris decreased in size. This case report has a detailed diagnosis and treatment process and sufficient examination results. It can provide a reference for diagnosing and treating patients with bilateral adrenal myelolipoma and DSD and reduce the risk of misdiagnosis and mistreatment.

Keywords: adrenal gland; adrenal myelolipoma; diagnosis; disorders of sex development (DSD); pathology.

Publication types

Case Reports

Grants and funding

This study was supported by Yunnan Education Department of Science Research Fund (Nos. 2023 J0295 and 2020J0228), Kunming City Health Science and Technology Talent “1000” training Project [No. 2020-SW (Reserve)-112], Kunming Health and Health Commission Health Research Project (No. 2020-0201-001), Kunming Medical Joint Project of Yunnan Science and Technology Department (No. 202001 AY070001-271), Department of Science and Technology of Yunnan province Kunming medicine Joint Special project (No.202301AY070001-108), and Open Research Fund of Clinical Research Center for Children’s Health and Diseases of Yunnan Province (No.2022-ETYY-YJ-03). The funding bodies played no role in the study’s design and collection, data analysis and interpretation, and manuscript writing.