Apoptotic enteropathy is a histological finding of increased crypt apoptosis that is commonly associated with diarrhea. Several etiologies for this disease state including immunodeficiency, autoimmune, infection, hereditary, checkpoint inhibitors, immunosuppressants, and immunomodulators have been previously described. We describe an extremely rare case of a patient with marginal cell lymphoma treated with bendamustine, rituximab, and obinutuzumab presenting with severe, relapsing, chronic diarrhea with persistent apoptotic enteropathy of unknown etiology, despite hematological remission and discontinuation of treatment for 1 year.
Keywords: apoptotic enteropathy; chornic diarrhea; immunosuppressive therapy; marginal cell lymphoma.
© 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.