Limb Saving with a Combination of Allogenic Platelets-Rich Plasma, Fibrin Glue, and Collagen Matrix in an Open Fracture of the Tibia: A Case Report

Hamid Reza Rahimi; Elaheh Emadi; Daryoush Hamidi Alamdari

doi:10.22038/ABJS.2023.69184.3261

Limb Saving with a Combination of Allogenic Platelets-Rich Plasma, Fibrin Glue, and Collagen Matrix in an Open Fracture of the Tibia: A Case Report

Arch Bone Jt Surg. 2023;11(8):535-538. doi: 10.22038/ABJS.2023.69184.3261.

Authors

Hamid Reza Rahimi¹, Elaheh Emadi², Daryoush Hamidi Alamdari³

Affiliations

¹ Department of Medical Genetics and Molecular Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Tibia open fractures and lower limb soft tissue injuries are undesired conditions for orthopedic and general surgeons, and there is no ideal procedure for treating recalcitrant ulcers or severe traumatic ulcers. Recently, several novel approaches have been proposed, such as bone marrow stem cells, platelets, fibrin glue, and collagen matrix. The current study was conducted to evaluate the effectiveness of combining platelets, fibrin glue, and a collagen matrix for treating a serious limb-threatening wound in a 33-year-old male with a right lower limb injury. After treatment, the wound was fully closed, tissue granulation was grown, skin grafting was done, and the right leg was saved. In conclusion, the combination of the mentioned components can be utilized to synergistically enhance wound healing and preserve the limb.

Keywords: Collagen matrix; Fibrin glue; Limb-threatening wound; Platelets-rich plasma.

Publication types

Case Reports