Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle

Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166877. doi: 10.1016/j.bbadis.2023.166877. Epub 2023 Sep 4.

Abstract

This study aimed to investigate the effects of cisplatin on adenosine triphosphate (ATP) levels, expressions of genes related to mitochondrial oxidative phosphorylation (OXPHOS), and the factors related to mitochondrial biosynthesis in skeletal muscle. Systemic cisplatin administration decreased skeletal muscle mass, skeletal muscle strength, and endurance. The mitochondrial DNA /nuclear DNA ratio was also reduced after treatment with cisplatin. Moreover, among the factors related to mitochondrial biogenesis and function, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was significantly downregulated in the cisplatin-treated group. Downregulation of PGC-1α in the skeletal muscle may contribute to muscle weakness during cisplatin-induced muscle atrophy.

Keywords: ATP; Cisplatin; Mitochondria; Muscle atrophy; PGC-1α.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cisplatin* / adverse effects
  • DNA, Mitochondrial / metabolism
  • Down-Regulation
  • Mice
  • Muscle, Skeletal / metabolism
  • Muscular Atrophy / chemically induced
  • Muscular Atrophy / genetics
  • Muscular Atrophy / metabolism
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism

Substances

  • Cisplatin
  • Transcription Factors
  • DNA, Mitochondrial
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha