Synergistic Effects of Rotavirus and Co-Infecting Viral Enteric Pathogens on Diarrheal Disease - Guangzhou City, Guangdong Province, China, 2019

Shunxian Zhang; Liguang Tian; Yan Lu; Lei Wang; Wenwen Lyu; Jinxin Zheng; Shan Lyu; Lili Pang; Guobing Yang; Hongli Wang; Ruitao Liu; Guanhua Chen; Jichun Wang

doi:10.46234/ccdcw2023.138

Synergistic Effects of Rotavirus and Co-Infecting Viral Enteric Pathogens on Diarrheal Disease - Guangzhou City, Guangdong Province, China, 2019

China CDC Wkly. 2023 Aug 18;5(33):725-730. doi: 10.46234/ccdcw2023.138.

Authors

Shunxian Zhang¹, Liguang Tian^{2

3}, Yan Lu^{2

3}, Lei Wang¹, Wenwen Lyu⁴, Jinxin Zheng^{2

3}, Shan Lyu^{2

3}, Lili Pang⁵, Guobing Yang⁶, Hongli Wang⁷, Ruitao Liu⁷, Guanhua Chen⁷, Jichun Wang⁸

Affiliations

¹ Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research On Tropical Diseases, National Institute of Parasitic Diseases, Shanghai, China.
³ School of Global Health, Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁴ Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁵ National Health Commission (NHC) Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
⁶ Gansu Provincial Center for Disease Control and Prevention, Lanzhou City, Gansu Province, China.
⁷ Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China.
⁸ Department of Science and Technology, Chinese Center for Disease Control and Prevention, Beijing, China.

Abstract

What is already known about this topic?: Diarrhea represents a substantial public health issue, contributing globally to a high number of pediatric medical consultations, hospital admissions, and mortality rates.

What is added by this report?: An increase in diarrheal frequency serves as a critical benchmark for evaluating severity. The predominant pathogens associated with pediatric diarrhea are rotavirus and norovirus, with co-infections exerting a notable compounding effect that leads to more severe diarrhea.

What are the implications for public health practice?: Implementing sensitive diagnostic techniques and comprehensive monitoring is paramount in identifying co-infections. Such strategies can provide physicians with critical insights into disease progression, thus considerably reducing the burden of diarrhea.

Keywords: Co-infection; Diarrhea; Severity; Synergistic effect.

Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2023.

Grants and funding

Supported by the Three-year Action Plan for Promoting Clinical Skills and Innovation Ability of Municipal Hospitals (SHDC2022CRS039), Shanghai Natural Science Foundation (22ZR1462100, 23ZR1464000, 23ZR1463900), Medical Innovation Research Special Project of the Shanghai 2021 “Science and Technology Innovation Action Plan” (21Y11922500, 21Y11922400), the Talent Fund of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine (LH001.007), Natural Science Foundation of Gansu Province (21JR11RA182), Research Ward Construction Project of Shanghai Hospital Development Center (SHDC2022CRW006), and Shanghai Municipal Education Commission Collaborative Innovation Center (A1-U21-205-902)