Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting

Mirna Chehade; Benjamin L Wright; Dan Atkins; Seema S Aceves; Steven J Ackerman; Amal H Assa'ad; Maureen Bauer; Margaret H Collins; Scott P Commins; Carla M Davis; Evan S Dellon; Bethan Doerfler; Gerald J Gleich; Sandeep K Gupta; David A Hill; Elizabeth T Jensen; David Katzka; Kara Kliewer; Ellyn Kodroff; Leah C Kottyan; Shay Kyle; Amanda B Muir; Robert D Pesek; Kathryn Peterson; Wayne G Shreffler; Jonathan M Spergel; Mary Jo Strobel; Joshua Wechsler; Nives Zimmermann; Glenn T Furuta; Marc E Rothenberg

doi:10.1016/j.jaci.2023.08.021

Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting

J Allergy Clin Immunol. 2023 Dec;152(6):1382-1393. doi: 10.1016/j.jaci.2023.08.021. Epub 2023 Sep 3.

Authors

Mirna Chehade¹, Benjamin L Wright², Dan Atkins³, Seema S Aceves⁴, Steven J Ackerman⁵, Amal H Assa'ad⁶, Maureen Bauer³, Margaret H Collins⁶, Scott P Commins⁷, Carla M Davis⁸, Evan S Dellon⁹, Bethan Doerfler¹⁰, Gerald J Gleich¹¹, Sandeep K Gupta¹², David A Hill¹³, Elizabeth T Jensen¹⁴, David Katzka¹⁵, Kara Kliewer⁶, Ellyn Kodroff¹⁶, Leah C Kottyan¹⁷, Shay Kyle¹⁶, Amanda B Muir¹³, Robert D Pesek¹⁸, Kathryn Peterson¹⁹, Wayne G Shreffler²⁰, Jonathan M Spergel¹³, Mary Jo Strobel²¹, Joshua Wechsler²², Nives Zimmermann⁶, Glenn T Furuta³, Marc E Rothenberg⁶

Affiliations

¹ Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: mirna.chehade@mssm.edu.
² Division of Allergy, Asthma, and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Ariz; Section of Allergy and Immunology, Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Ariz.
³ Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colo.
⁴ Rady Children's Hospital, San Diego, Calif; Division of Allergy, Immunology, University of California-San Diego, San Diego, Calif.
⁵ Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Ill.
⁶ Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁷ Division of Allergy & Immunology, Center for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁸ Division of Immunology, Allergy, and Retrovirology, Baylor College of Medicine, Houston, Tex; Texas Children's Hospital Food Allergy Program, Texas Children's Hospital, Houston, Tex.
⁹ Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC.
¹⁰ Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Chicago, Ill.
¹¹ Department of Dermatology, School of Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
¹² Children's of Alabama, University of Alabama at Birmingham, Birmingham, Ala.
¹³ Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa; Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pa.
¹⁴ Wake Forest University School of Medicine, Winston-Salem, NC.
¹⁵ Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY.
¹⁶ Campaign Urging Research for Eosinophilic Disease, Lincolnshire, Ill.
¹⁷ Cincinnati Children's Research Foundation, Division of Human Genetics, Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
¹⁸ Division of Allergy/Immunology, University of Arkansas for Medicine Sciences, Little Rock, Ark; Arkansas Children's Hospital, Little Rock, Ark.
¹⁹ Division of Gastroenterology, University of Utah Health, Salt Lake City, Utah.
²⁰ Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Mass; Harvard Medical School, Massachusetts General Hospital, Boston, Mass; Food Allergy Center, Massachusetts General Hospital, Boston, Mass.
²¹ American Partnership for Eosinophilic Disorders, Atlanta, Ga.
²² Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.

PMID: 37660987
DOI: 10.1016/j.jaci.2023.08.021

Abstract

The Consortium of Eosinophilic Gastrointestinal Diseases and The International Gastrointestinal Eosinophil Researchers organized a day-long symposium at the 2022 Annual Meeting of the American Academy of Allergy, Asthma & Immunology. The symposium featured a review of recent discoveries in the basic biology and pathogenesis of eosinophilic gastrointestinal diseases (EGIDs) in addition to advances in our understanding of the clinical features of EGIDs. Diagnostic and management approaches were reviewed and debated, and clinical trials of emerging therapies were highlighted. Herein, we briefly summarize the breakthrough discoveries in EGIDs.

Keywords: Eosinophilic esophagitis; eosinophil; eosinophilic gastritis; food allergy.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Asthma* / diagnosis
Asthma* / therapy
Enteritis* / diagnosis
Enteritis* / therapy
Eosinophilia*
Eosinophilic Esophagitis*
Gastritis*
Humans
United States

Supplementary concepts

Eosinophilic enteropathy

Abstract

Publication types

MeSH terms

Supplementary concepts

Grants and funding