Successful treatment of large area oral verrucous hyperplasia using diode laser ablation combined with photodynamic therapy: A case report

Yuan Liu; Zeyu Liu; Bingjie Dong; Wenjin Tong; Rui Lu

doi:10.1016/j.pdpdt.2023.103769

Successful treatment of large area oral verrucous hyperplasia using diode laser ablation combined with photodynamic therapy: A case report

Photodiagnosis Photodyn Ther. 2023 Dec:44:103769. doi: 10.1016/j.pdpdt.2023.103769. Epub 2023 Aug 26.

Authors

Yuan Liu¹, Zeyu Liu², Bingjie Dong², Wenjin Tong², Rui Lu³

Affiliations

¹ State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University; Department of Oral Medicine, School & Hospital of Stomatology, Wuhan University; Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
² State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University; Department of Oral Medicine, School & Hospital of Stomatology, Wuhan University.
³ State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University; Department of Oral Medicine, School & Hospital of Stomatology, Wuhan University. Electronic address: lurui@whu.edu.cn.

PMID: 37640208
DOI: 10.1016/j.pdpdt.2023.103769

Abstract

Oral verrucous hyperplasia (OVH) refers to a whitish or pink elevated plaque or mass on the oral mucosa with either verrucous or papillary surface. Given its potential of malignant transformation, it is crucial to pursue aggressive treatment and close surveillance to the lesion. Herein, we present a case of a 43-year-old male patient with large area OVH on the left buccal mucosa who was successfully treated using diode laser ablation combined with 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT). After two sessions of treatment, the lesions regressed completely, and no recurrence was observed at the 18-month follow-up. Therefore, diode laser ablation combined with ALA-PDT may be an efficient and safe treatment modality for large area OVH.

Keywords: 5-aminolevulinic acid-mediated photodynamic therapy; Diode laser; Oral verrucous hyperplasia; Photodynamic Therapy; Pretreatment.

Publication types

Case Reports

MeSH terms

Adult
Aminolevulinic Acid / therapeutic use
Humans
Hyperplasia / complications
Hyperplasia / drug therapy
Laser Therapy* / adverse effects
Male
Mouth Neoplasms* / drug therapy
Photochemotherapy* / methods
Photosensitizing Agents / therapeutic use
Treatment Outcome

Substances

Photosensitizing Agents
Aminolevulinic Acid