Inflammatory reactions mimic residual or recurrent lymphoma on [18F]FDG-PET/CT after CD19-directed CAR T-cell therapy

Janneke W de Boer; Elise R A Pennings; Ankie Kleinjan; Jaap A van Doesum; Anne M Spanjaart; Pim G N J Mutsaers; Margot Jak; Marjolein W M van der Poel; Maria T Kuipers; Judit A Adam; Arjan Diepstra; Lianne Koens; Suzanne van Dorp; Joost S P Vermaat; Anne G H Niezink; Marie José Kersten; Tom van Meerten

doi:10.1182/bloodadvances.2023010665

Inflammatory reactions mimic residual or recurrent lymphoma on [18F]FDG-PET/CT after CD19-directed CAR T-cell therapy

Blood Adv. 2023 Nov 14;7(21):6710-6716. doi: 10.1182/bloodadvances.2023010665.

Authors

Janneke W de Boer¹, Elise R A Pennings^{2

3

4

5}, Ankie Kleinjan⁶, Jaap A van Doesum¹, Anne M Spanjaart^{2

3

4}, Pim G N J Mutsaers⁷, Margot Jak⁸, Marjolein W M van der Poel⁹, Maria T Kuipers^{3

10}, Judit A Adam^{3

11}, Arjan Diepstra¹², Lianne Koens¹³, Suzanne van Dorp¹⁴, Joost S P Vermaat¹⁵, Anne G H Niezink¹⁶, Marie José Kersten^{2

3

4}, Tom van Meerten¹

Affiliations

¹ Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands.
² Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
³ Cancer Center Amsterdam, Amsterdam, The Netherlands.
⁴ LYMMCARE (Lymphoma and Myeloma Center Amsterdam), Amsterdam, The Netherlands.
⁵ Erasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.
⁶ Department of Internal Medicine, Rivierenland Hospital, Tiel, The Netherlands.
⁷ Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
⁸ Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands.
⁹ Department of Internal Medicine, Division of Hematology, GROW school for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
¹⁰ Department of Hematology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
¹¹ Department of Radiology and Nuclear Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
¹² Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
¹³ Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
¹⁴ Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
¹⁵ Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
¹⁶ Department of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, CD19
Fluorodeoxyglucose F18*
Humans
Immunotherapy, Adoptive
Lymphoma* / therapy
Neoplasm Recurrence, Local / diagnostic imaging
Positron Emission Tomography Computed Tomography

Substances

Fluorodeoxyglucose F18
Antigens, CD19