Ferroptosis regulation by methylation in cancer

Mengqiu Hao; Yixin Jiang; Yang Zhang; Xuyang Yang; Junhong Han

doi:10.1016/j.bbcan.2023.188972

Ferroptosis regulation by methylation in cancer

Biochim Biophys Acta Rev Cancer. 2023 Nov;1878(6):188972. doi: 10.1016/j.bbcan.2023.188972. Epub 2023 Aug 26.

Authors

Mengqiu Hao¹, Yixin Jiang¹, Yang Zhang², Xuyang Yang³, Junhong Han⁴

Affiliations

¹ Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China.
² Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China; Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China; Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
³ Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China; Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China; Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: yangxuyang@wchscu.cn.
⁴ Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China. Electronic address: hjunhong@scu.edu.cn.

PMID: 37634887
DOI: 10.1016/j.bbcan.2023.188972

Abstract

Epigenetic regulation plays a critical role in cancer development and progression. Methylation is an important epigenetic modification that influences gene expression by adding a methyl group to nucleic acids and proteins. Ferroptosis is a new form of regulated cell death triggered by the accumulation of iron and lipid peroxidation. Emerging evidence have shown that methylation regulation plays a significant role in the regulation of ferroptosis in cancer. This review aims to explore the methylation regulation of ferroptosis in cancer, including reactive oxygen species and iron bio-logical activity, amino acid and lipid metabolism, and drugs interaction. The findings of this review may provide new insights and strategies for the prevention and treatment of cancer.

Keywords: Cancer; Drugs; Epigenetic; Ferroptosis; Methylation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Death / genetics
Epigenesis, Genetic
Ferroptosis* / genetics
Humans
Iron / metabolism
Methylation
Neoplasms* / genetics
Neoplasms* / therapy

Substances

Iron