Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive

Rosie E Curiel Cid; Alexandra Ortega; Elizabeth A Crocco; Diana Hincapie; Karen N McFarland; Ranjan Duara; David Vaillancourt; Steven T DeKosky; Glenn Smith; Efrosyni Sfakianaki; Monica Rosselli; Warren W Barker; Malek Adjouadi; Yarlenis Barreto; Yuleidys Feito; David A Loewenstein

doi:10.3389/fneur.2023.1179205

Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive

Front Neurol. 2023 Aug 4:14:1179205. doi: 10.3389/fneur.2023.1179205. eCollection 2023.

Authors

Rosie E Curiel Cid¹, Alexandra Ortega¹, Elizabeth A Crocco¹, Diana Hincapie¹, Karen N McFarland², Ranjan Duara², David Vaillancourt³, Steven T DeKosky⁴, Glenn Smith⁵, Efrosyni Sfakianaki¹, Monica Rosselli⁶, Warren W Barker⁷, Malek Adjouadi⁸, Yarlenis Barreto¹, Yuleidys Feito¹, David A Loewenstein¹

Affiliations

¹ Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States.
² Department of Neurology and the Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, United States.
³ Department of Applied Physiology and Kinesiology, Gainesville, FL, United States.
⁴ Department of Neurology and McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
⁵ Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States.
⁶ Department of Psychology, Florida Atlantic University, Boca Raton, FL, United States.
⁷ Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, FL, United States.
⁸ Center for Advanced Technology and Education, Florida International University, Miami, FL, United States.

Abstract

Introduction: Semantic intrusion errors (SI) have distinguished between those with amnestic Mild Cognitive Impairment (aMCI) who are amyloid positive (A+) versus negative (A-) on positron emission tomography (PET).

Method: This study examines the association between SI and plasma - based biomarkers. One hundred and twenty-eight participants received SiMoA derived measures of plasma pTau-181, ratio of two amyloid-β peptide fragments (Aβ42/Aβ40), Neurofilament Light protein (NfL), Glial Fibrillary Acidic Protein (GFAP), ApoE genotyping, and amyloid PET imaging.

Results: The aMCI A+ (n = 42) group had a higher percentage of ApoE ɛ4 carriers, and greater levels of pTau-181 and SI, than Cognitively Unimpaired (CU) A- participants (n = 25). CU controls did not differ from aMCI A- (n = 61) on plasma biomarkers or ApoE genotype. Logistic regression indicated that ApoE ɛ4 positivity, pTau-181, and SI were independent differentiating predictors (Correct classification = 82.0%; Sensitivity = 71.4%; Specificity = 90.2%) in identifying A+ from A- aMCI cases.

Discussion: A combination of plasma biomarkers, ApoE positivity and SI had high specificity in identifying A+ from A- aMCI cases.

Keywords: ApoE; LASSI-L; inhibitory control; mild cognitive impairment; p-tau amyloid; plasma biomarkers; semantic intrusions; sematic interference.