The role of macrophage ion channels in the progression of atherosclerosis

Xin Wu; Sidhant Singla; Jianhua J Liu; Liang Hong

doi:10.3389/fimmu.2023.1225178

The role of macrophage ion channels in the progression of atherosclerosis

Front Immunol. 2023 Jul 31:14:1225178. doi: 10.3389/fimmu.2023.1225178. eCollection 2023.

Authors

Xin Wu¹, Sidhant Singla¹, Jianhua J Liu², Liang Hong^{1

3}

Affiliations

¹ Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States.
² Department of Pathology, University of Illinois at Chicago, Chicago, IL, United States.
³ Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, United States.

Abstract

Atherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulate macrophage activation, polarization, phagocytosis, and cytokine secretion. Moreover, macrophage ion channel dysfunction is implicated in macrophage-derived foam cell formation and atherogenesis. In this context, exploring the regulatory role of ion channels in macrophage function and their impacts on the progression of atherosclerosis emerges as a promising avenue for research. Studies in the field will provide insights into novel therapeutic targets for the treatment of atherosclerosis.

Keywords: atherosclerosis; foam cell formation; inflammatory disease; ion channel; macrophage.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Atherosclerosis*
Foam Cells
Humans
Macrophages
Myocardial Infarction*
Phagocytosis

Abstract

Publication types

MeSH terms

Grants and funding