The role of DNA methylation in personalized medicine for immune-related diseases

Manoj Kumar Gupta; He Peng; Yang Li; Cheng-Jian Xu

doi:10.1016/j.pharmthera.2023.108508

The role of DNA methylation in personalized medicine for immune-related diseases

Pharmacol Ther. 2023 Oct:250:108508. doi: 10.1016/j.pharmthera.2023.108508. Epub 2023 Aug 9.

Authors

Manoj Kumar Gupta¹, He Peng¹, Yang Li², Cheng-Jian Xu³

Affiliations

¹ Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
² Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany; Department of Internal Medicine and Radboud Institute for Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
³ Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany; Department of Internal Medicine and Radboud Institute for Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Xu.Chengjian@mh-hannover.de.

PMID: 37567513
DOI: 10.1016/j.pharmthera.2023.108508

Abstract

Epigenetics functions as a bridge between host genetic & environmental factors, aiding in human health and diseases. Many immune-related diseases, including infectious and allergic diseases, have been linked to epigenetic mechanisms, particularly DNA methylation. In this review, we summarized an updated overview of DNA methylation and its importance in personalized medicine, and demonstrated that DNA methylation has excellent potential for disease prevention, diagnosis, and treatment in a personalized manner. The future implications and limitations of the DNA methylation study have also been well-discussed.

Keywords: DNA methylation; Epigenetics; Personalized medicine.

Publication types

Review

MeSH terms

DNA Methylation*
Epigenesis, Genetic
Epigenomics
Humans
Hypersensitivity* / genetics
Precision Medicine