The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread

PLoS One. 2023 Aug 10;18(8):e0288911. doi: 10.1371/journal.pone.0288911. eCollection 2023.

Abstract

In this study, the influences of mulberry leaf extract (MLE) addition on the physicochemical properties including the specific volume, texture and sensory features of white bread (WB) were evaluated by the sensory analysis technology. A double-blind, randomised, repeat-measure design was used to study the impact of MLE addition on the postprandial blood glucose response as well as the satiety index of WB. Results showed that the addition of MLE showed no significant effects on the physicochemical properties of WB except for the slight changes of color and bitterness. The addition of MLE significantly reduced the total blood glucose rise after ingestion of WB over 120 minutes, and reduced the GI value of WB in a dose-effect relationship. When the concentration of MLE reached 1.5 g per 100 g available carbohydrate, the GI value of WB could be reduced from 77 to 43. This study provides important information in terms of the appropriateness of MLE when added to more complex real food, the dose-dependent relationship could supply a reference for the application of MLE.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / analysis
  • Blood Glucose / drug effects
  • Bread* / adverse effects
  • Cross-Over Studies
  • Double-Blind Method
  • Glycemic Index* / drug effects
  • Humans
  • Insulin
  • Morus* / chemistry
  • Plant Extracts* / pharmacology
  • Postprandial Period
  • Triticum

Substances

  • Blood Glucose
  • Insulin
  • Plant Extracts

Grants and funding

The study was funded by the following sources: Beijing Municipal Science & Technology Commission (Z191100008619006) awarded to WC, Hebei Provincial Department of Science and Technology (21327118D) awarded to SD, and Science and Technology Department of Tibet (XZ202101YD0019C) awarded to SD. The funders are responsible for supervising and guiding the implementation of the entire research plan.