Abstract
A monoclonal antibody against the fusion (F) protein of mumps virus was found to confer marked protection in mumps virus-induced encephalitis. Almost total prevention of extensive brain necrosis was found. This study indicates that the virus F protein is directly involved in the pathogenesis of brain necrosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Antibodies, Monoclonal / immunology*
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Brain / microbiology
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Cricetinae
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Meningoencephalitis / immunology*
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Meningoencephalitis / microbiology
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Meningoencephalitis / prevention & control
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Mumps virus / immunology*
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Viral Envelope Proteins / immunology*
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Viral Fusion Proteins
Substances
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Antibodies, Monoclonal
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Viral Envelope Proteins
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Viral Fusion Proteins