Abstract
A possibility of the androgen's correction of spontaneous and transplanted leukogenesis has been investigated in AKR mice. Prolongation of life was observed in the animals treated with the hormone at early stages of the leukemia development. The obtained results may be related to the stem hemopoietic precursors differentiation change under the testosterone influence manifested by erythropoiesis stimulation and the reduction of granulocytic colonies determined by the growth in the cellulose-acetate membranes (CFUcam).
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Androgens / therapeutic use*
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Animals
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Colony-Forming Units Assay
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Dactinomycin / therapeutic use
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Drug Evaluation, Preclinical
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Erythropoiesis / drug effects
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Hematopoietic Stem Cells / drug effects
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Leukemia, Experimental / drug therapy
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Leukemia, Experimental / etiology*
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Leukemia, Experimental / mortality
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Mice
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Mice, Inbred AKR*
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Neoplasm Transplantation
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Peptides / therapeutic use
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Testosterone / therapeutic use
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Thymus Extracts / therapeutic use
Substances
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Androgens
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Peptides
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Thymus Extracts
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Dactinomycin
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Testosterone
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T-activin