Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?

Pharmacol Res. 2023 Aug:194:106869. doi: 10.1016/j.phrs.2023.106869. Epub 2023 Jul 28.

Authors

Hang Gong¹, Hui-Mei Xu¹, Yao-Hui Ma¹, De-Kui Zhang²

Affiliations

¹ Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China.
² Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China. Electronic address: zhangdk8616@126.com.

PMID: 37517563
DOI: 10.1016/j.phrs.2023.106869

No abstract available

Keywords: Glycolysis; Histone lactylation; Lactate; Liver cancer; Tumorigenicity.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Histones
Lactic Acid*
Liver
Neoplasms*
Neoplastic Stem Cells

Substances

Lactic Acid
Histones
demethylzeylasteral