First evidence of in vivo effect of FLASH radiotherapy with helium ions in zebrafish embryos

Youssef Ghannam; Sophie Chiavassa; Gaëlle Saade; Charbel Koumeir; Guillaume Blain; Grégory Delpon; Manon Evin; Ferid Haddad; Lydia Maigne; Quentin Mouchard; Noël Servagent; Vincent Potiron; Stéphane Supiot

doi:10.1016/j.radonc.2023.109820

First evidence of in vivo effect of FLASH radiotherapy with helium ions in zebrafish embryos

Radiother Oncol. 2023 Oct:187:109820. doi: 10.1016/j.radonc.2023.109820. Epub 2023 Jul 27.

Authors

Affiliations

¹ CNRS, UMR 6286, Nantes Université, France.
² Laboratoire SUBATECH, UMR 6457 CNRS-IN2P3, IMT Atlantique, Nantes Université, France; Institut de Cancérologie de l'Ouest, site Saint-Herblain, France.
³ Laboratoire SUBATECH, UMR 6457 CNRS-IN2P3, IMT Atlantique, Nantes Université, France; GIP ARRONAX, Saint-Herblain, France.
⁴ Laboratoire SUBATECH, UMR 6457 CNRS-IN2P3, IMT Atlantique, Nantes Université, France.
⁵ Université Clermont Auvergne, CNRS/IN2P3, LPC, 63000, Clermont-Ferrand, France.
⁶ CNRS, UMR 6286, Nantes Université, France; Institut de Cancérologie de l'Ouest, site Saint-Herblain, France. Electronic address: vincent.potiron@ico.unicancer.fr.
⁷ CNRS, UMR 6286, Nantes Université, France; Institut de Cancérologie de l'Ouest, site Saint-Herblain, France.

PMID: 37516363
DOI: 10.1016/j.radonc.2023.109820

Abstract

The ability to reduce toxicity of ultra-high dose rate (UHDR) helium ion irradiation has not been reported in vivo. Here, we tested UHDR helium ion irradiation in an embryonic zebrafish model. Our results show that UHDR helium ions spare body development and reduce spine curvature, compared to conventional dose rate.

Keywords: FLASH; Helium ion; Radiotherapy; UHDR; Zebrafish.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Helium* / therapeutic use
Ions / therapeutic use
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted / methods
Zebrafish*

Substances

Helium
Ions