Brain metastasis and intracranial leptomeningeal metastasis from malignant peripheral nerve sheath tumors: illustrative cases

Masasuke Ohno; Shoichi Haimoto; Satoshi Tsukushi; Waki Hosoda; Fumiharu Ohka; Ryuta Saito

doi:10.3171/CASE23148

Brain metastasis and intracranial leptomeningeal metastasis from malignant peripheral nerve sheath tumors: illustrative cases

J Neurosurg Case Lessons. 2023 Jul 17;6(3):CASE23148. doi: 10.3171/CASE23148. Print 2023 Jul 17.

Authors

Masasuke Ohno¹, Shoichi Haimoto¹, Satoshi Tsukushi², Waki Hosoda³, Fumiharu Ohka⁴, Ryuta Saito⁴

Affiliations

¹ Departments of1Neurosurgery.
² 2Orthopaedic Surgery, and.
³ 3Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan; and.
⁴ 4Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Abstract

Background: Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft-tissue tumors. Intracranial metastasis from MPNSTs is quite rare.

Observations: The authors report on a 73-year-old male whose MPNST metastasized to the brain and a 32-year-old male with leptomeningeal metastasis from MPNST and review 41 cases of MPNST that developed intracranial metastasis, as reported in the literature.

Lessons: Brain metastasis and leptomeningeal metastasis of MPNSTs show different clinical courses and require pathology-specific treatment.

Keywords: brain metastasis; leptomeningeal metastasis; malignant peripheral nerve sheath tumor.