Imaging biomarker for quantitative analysis of endometrial injury based on optical coherence tomography/ultrasound integrated imaging mode

Meng Du; Jinke Zhang; Ting Wang; Jinghui Fang; Hanyinghong Su; Zhang Xiao; Yingao Peng; Xiaowen Liang; Xiaojing Gong; Zhiyi Chen

doi:10.1002/jbio.202300113

Imaging biomarker for quantitative analysis of endometrial injury based on optical coherence tomography/ultrasound integrated imaging mode

J Biophotonics. 2023 Dec;16(12):e202300113. doi: 10.1002/jbio.202300113. Epub 2023 Sep 4.

Authors

Meng Du^{1

2}, Jinke Zhang³, Ting Wang^{1

2}, Jinghui Fang⁴, Hanyinghong Su², Zhang Xiao⁵, Yingao Peng², Xiaowen Liang², Xiaojing Gong³, Zhiyi Chen^{1

2

6}

Affiliations

¹ The First Affiliated Hospital, Medical Imaging Centre, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
² Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang, China.
³ The Research Center for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
⁴ Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁵ College of Mechanical Engineering, University of South China, Hengyang, China.
⁶ The Seventh Affiliated Hospital University of South China/ Hunan Veterans Administration Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

PMID: 37483072
DOI: 10.1002/jbio.202300113

Abstract

Precise evaluation of endometrial injury is significant to clinical decision-making in gynecological disease and assisted reproductive technology. However, there is a lack of assessment methods for endometrium in vivo. In this research, we intend to develop quantitative imaging markers with optical coherence tomography (OCT)/ultrasound (US) integrated imaging system through intrauterine endoscopic imaging. OCT/US integrated imaging system was established as our previous research reported. The endometrial injury model was established and after treatment, OCT/US integrated imaging and uterus biopsy was performed to evaluate the endometrial thickness, number of superficial fold, and intrauterine area. According to the results, three quantitative indexes acquired from OCT/US image and HE staining have the same trend and have a strong relationship with the severity of the endometrial injury. Accordingly, we developed three imaging markers for quantitative analysis of endometrial injury in vivo, which provided a precise mode for endometrium evaluation in clinical practice.

Keywords: endometrial injury; endoscopic imaging; imaging biomarker; optical coherence tomography; quantitative analysis; ultrasound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biopsy
Endometrium* / diagnostic imaging
Endometrium* / pathology
Female
Humans
Tomography, Optical Coherence* / methods
Ultrasonography

Abstract

Publication types

MeSH terms

Grants and funding