'Yapping' with extracellular vesicles in fatty liver metastasis

Ramaroson Andriantsitohaina; M Carmen Martinez

doi:10.1016/j.tcb.2023.07.001

'Yapping' with extracellular vesicles in fatty liver metastasis

Trends Cell Biol. 2023 Sep;33(9):729-731. doi: 10.1016/j.tcb.2023.07.001. Epub 2023 Jul 18.

Authors

Ramaroson Andriantsitohaina¹, M Carmen Martinez²

Affiliations

¹ Physiologie et Médecine Experimentale du Coeur et des Muscles (PhyMedExp), Université de Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1046, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 9214, Montpellier, France. Electronic address: ramaroson.andriantsitohaina@inserm.fr.
² Physiologie et Médecine Experimentale du Coeur et des Muscles (PhyMedExp), Université de Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1046, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 9214, Montpellier, France.

PMID: 37468354
DOI: 10.1016/j.tcb.2023.07.001

Abstract

Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). A recent study by Wang et al. has deciphered unprecedented prometastatic and immunosuppressive properties of the tumor microenvironment (TME) mediated by hepatocyte-derived extracellular vesicles (EVs) in fatty liver, paving the way for therapeutic innovations to treat patients with CRC and liver metastasis.

Keywords: colorectal cancer; extracellular vesicles; liver metastasis; tumor environment.

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MeSH terms

Extracellular Vesicles*
Fatty Liver*
Humans
Liver Neoplasms* / pathology
Liver Neoplasms* / secondary
Tumor Microenvironment