Impaired Insulin Signaling Alters Mediators of Hippocampal Synaptic Dynamics/Plasticity: A Possible Mechanism of Hyperglycemia-Induced Cognitive Impairment

Mubeen A Ansari; Aishah Al-Jarallah; Fawzi A Babiker

doi:10.3390/cells12131728

Impaired Insulin Signaling Alters Mediators of Hippocampal Synaptic Dynamics/Plasticity: A Possible Mechanism of Hyperglycemia-Induced Cognitive Impairment

Cells. 2023 Jun 27;12(13):1728. doi: 10.3390/cells12131728.

Authors

Mubeen A Ansari¹, Aishah Al-Jarallah², Fawzi A Babiker³

Affiliations

¹ Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait City 13110, Kuwait.
² Department of Biochemistry, Faculty of Medicine, Kuwait University, Kuwait City 13110, Kuwait.
³ Department of Physiology, Faculty of Medicine, Kuwait University, Kuwait City 13110, Kuwait.

Abstract

Alzheimer's disease (AD) is a neurological condition that affects the elderly and is characterized by progressive and irreversible neurodegeneration in the cerebral cortex [...].

Keywords: Na+/K+-ATPase; acetylcholine esterase; cognitive behavior; streptozotocin; synapse.

MeSH terms

Acetylcholinesterase / metabolism
Animals
Cognitive Dysfunction* / etiology
Cognitive Dysfunction* / metabolism
Disease Models, Animal
Hippocampus* / physiopathology
Hyperglycemia* / chemically induced
Hyperglycemia* / complications
Hyperglycemia* / metabolism
Insulin* / metabolism
Male
Maze Learning
Neuronal Plasticity*
Phosphatidylinositol 3-Kinase / metabolism
Phosphorylation
Proto-Oncogene Proteins c-akt / metabolism
Rats
Rats, Wistar
Signal Transduction
Sodium-Potassium-Exchanging ATPase / metabolism
Streptozocin
Synapses* / metabolism
Synaptosomes

Substances

Insulin
Streptozocin
Acetylcholinesterase
Sodium-Potassium-Exchanging ATPase
Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-akt

Grants and funding

This research received no external funding.