Th1-like Treg cells are dressed to suppress anti-tumor immunity

Delaney E Ramirez; Mary Jo Turk

doi:10.1016/j.immuni.2023.06.014

Th1-like Treg cells are dressed to suppress anti-tumor immunity

Immunity. 2023 Jul 11;56(7):1437-1439. doi: 10.1016/j.immuni.2023.06.014.

Authors

Delaney E Ramirez¹, Mary Jo Turk²

Affiliations

¹ Dartmouth Cancer Center and the Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, NH, USA.
² Dartmouth Cancer Center and the Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, Lebanon, NH, USA. Electronic address: mary.jo.turk@dartmouth.edu.

Abstract

Mechanisms of Th1-like Treg suppression are unknown in cancer. Two studies in Immunity by Ayala et al. and Zagorulya et al. demonstrate that Th1-like Treg cells interact with type 1 dendritic cells in tumors and draining lymph nodes to potently suppress anti-tumor immunity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Dendritic Cells* / immunology
Lymph Nodes
Neoplasms* / immunology
T-Lymphocytes, Regulatory* / immunology

Abstract

Publication types

MeSH terms

Grants and funding